Evaluation of Galectin-3 Plasma Concentration in Adolescents with Ventricular Arrhythmia
Open Access
- 2 March 2021
- journal article
- research article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 18 (5), 2410
- https://doi.org/10.3390/ijerph18052410
Abstract
Galectin-3 (G3) is a biomarker known as an inflammatory state exponent. The aim of this paper was to analyze the G3 in adolescents with ventricular arrhythmia (VES) in order to evaluate its impact on myocardial tissue preservation. The study group (SG) consisted of 25 VES adolescents. The control group (CG) was 21 healthy children. G3 was assessed in the SG and CG. In the SG electrocardiography, Holter monitoring, echocardiography and CMR were performed. The G3 in SG was 13.45 ± 11.4 ng/mL and in CG 7.2 ± 2.0 ng/mL, p < 0.001. Moderate positive correlation between the G3 and z-score of the left ventricular diameter (r = 0.47, p = 0.041) and moderate negative correlation between the G3 and the left ventricular ejection fraction in cardiac magnetic resonance (CMR EF) (−0.49, p = 0.032) were found. According to the multiple linear regression analysis, CMR EF and VES were independent predictors for G3 elevation. Conclusion: Galectin-3 plasma concentration is elevated and correlates with the chosen left ventricular dysfunction parameters in adolescents suffering from ventricular arrhythmia. Further investigation is necessary to establish if elevated G3 is a useful biomarker for screening young individuals with ventricular arrhythmia who are at risk of structural cardiovascular pathology.This publication has 31 references indexed in Scilit:
- Biomarkers of Myocardial Stress and Fibrosis as Predictors of Mode of Death in Patients With Chronic Heart FailureJACC: Heart Failure, 2014
- Prevalence and Prognostic Value of Concealed Structural Abnormalities in Patients With Apparently Idiopathic Ventricular Arrhythmias of Left Versus Right Ventricular OriginCirculation: Arrhythmia and Electrophysiology, 2014
- PACES/HRS Expert Consensus Statement on the Evaluation and Management of Ventricular Arrhythmias in the Child With a Structurally Normal HeartHeart Rhythm, 2014
- Baseline and serial measurements of galectin‐3 in patients with heart failure: relationship to prognosis and effect of treatment with valsartan in the Val‐HeFTEuropean Journal of Heart Failure, 2013
- Galectin-3 in Ambulatory Patients With Heart FailureCirculation: Heart Failure, 2012
- Characteristics of Premature Ventricular Complexes as Correlates of Reduced Left Ventricular Systolic Function: Study of the Burden, Duration, Coupling Interval, Morphology and Site of Origin of PVCsJournal of Cardiovascular Electrophysiology, 2011
- Relationship between burden of premature ventricular complexes and left ventricular functionHeart Rhythm, 2010
- Cardiovascular Consequences of Completing a 160-km UltramarathonMedicine & Science in Sports & Exercise, 2009
- Guidelines and Standards for Performance of a Pediatric Echocardiogram: A Report from the Task Force of the Pediatric Council of the American Society of EchocardiographyJournal of the American Society of Echocardiography, 2006
- Cardiac arrhythmias in healthy children revealed by 24-hour ambulatory ECG monitoringPediatric Cardiology, 1987