Role of Emollients in Prevention of the Comorbid Allergic Diseases Development in Children with Atopic Dermatitis
Open Access
- 23 September 2020
- journal article
- Published by Paediatrician Publishers LLC in Pediatric pharmacology
- Vol. 17 (4), 334-339
- https://doi.org/10.15690/pf.v17i4.2160
Abstract
Atopic dermatitis (AD) is one of the common multifactorial inflammatory diseases manifesting predominantly in childhood. There is significant number of cases of self-regression of the disease with aging. On the other hand, there is also another scenario ending with AD persistent course and/or development of comorbid allergic pathologies that can significantly worsen patient’s quality of life and finally lead to social maladjustment. The pathogenesis of such way includes epidermal barrier disturbance, transcutaneous sensibilisation and aberrant allergic (Th2) immune systemic response development. Main role in preventing of this pathological pathway is lying on the new class of moisturizers containing active components "emollients plus". They are considered as foundation for the therapy and prevention of the development of AD and other allergic diseases. This literature review provides relevant data on AD pathogenesis and development of comorbid allergic pathologies. This paper also covers data on the effect of emollients in restoration of the epidermal barrier and their use as preventive measures.Keywords
This publication has 60 references indexed in Scilit:
- Management of Patients with Atopic Dermatitis: The Role of Emollient TherapyDermatology Research and Practice, 2012
- Skin Barrier Disruption: A Requirement for Allergen Sensitization?Journal of Investigative Dermatology, 2012
- Epidermal barrier dysfunction and cutaneous sensitization in atopic diseasesJCI Insight, 2012
- Functions of thymic stromal lymphopoietin in immunity and diseaseImmunologic Research, 2012
- A pilot study of emollient therapy for the primary prevention of atopic dermatitisJournal of the American Academy of Dermatology, 2010
- Abnormal skin barrier in the etiopathogenesis of atopic dermatitisCurrent Opinion in Allergy and Clinical Immunology, 2009
- “Outside-to-Inside” (and Now Back to “Outside”) Pathogenic Mechanisms in Atopic DermatitisJournal of Investigative Dermatology, 2008
- OX40-OX40L interactions: a promising therapeutic target for allergic diseases?JCI Insight, 2007
- Cytokine modulation of atopic dermatitis filaggrin skin expressionJournal of Allergy and Clinical Immunology, 2007
- Is allergy prevention realistic and beneficial?Pediatric Allergy and Immunology, 1999