The immune potential of ex vivo stored platelets: a review
Open Access
- 16 December 2020
- journal article
- review article
- Published by Wiley in Vox Sanguinis
- Vol. 116 (5), 477-488
- https://doi.org/10.1111/vox.13058
Abstract
Platelets are now acknowledged as key regulators of the immune system, as they are capable of mediating inflammation, leucocyte recruitment and activation. This activity is facilitated through platelet activation, which induces significant changes in the surface receptor profile and triggers the release of a range of soluble biological response modifiers (BRMs). In the field of transfusion medicine, the immune function of platelets has gained considerable attention as this may be linked to the development of adverse transfusion reactions. Further, component manufacturing and storage methodologies may impact the immunoregulatory role of platelets, and an understanding of this impact is crucial and should be considered alongside their haemostatic characteristics. This review highlights the key interactions between platelets and traditional immune modulators. Further, the potential impact of current and novel component storage methodologies, such as refrigeration and cryopreservation, on this functional capacity is examined, highlighting why further knowledge in this area would be of benefit.Keywords
This publication has 79 references indexed in Scilit:
- PAS‐G supports platelet reconstitution after cryopreservation in the absence of plasmaTransfusion, 2013
- Transfusion-Related Acute Lung Injury: The Work of DAMPs*Transfusion Medicine and Hemotherapy, 2013
- T granules in human platelets function in TLR9 organization and signalingThe Journal of cell biology, 2012
- Platelets induce neutrophil extracellular traps in transfusion-related acute lung injuryJCI Insight, 2012
- Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1β–Rich MicroparticlesThe Journal of Immunology, 2011
- Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injuryJCI Insight, 2009
- Platelet α-granules: Basic biology and clinical correlatesBlood Reviews, 2009
- Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesiclesBlood, 2008
- Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injuryBlood, 2006
- Evidence of Toll‐like receptor molecules on human plateletsImmunology & Cell Biology, 2005