Leukemia is defined as malignant neoplasm of blood-forming tissues, which characterized as abnormal proliferation of leukocytes. The main treatment includes chemotherapy, allogeneic hematopoietic stem cell transplantation, immunotherapy and cellular therapy. Recently, immunotherapy, is an emerging novel therapy and has achieved dramatic success in clinical practice, especially for chimeric antigen receptor (CAR) T-cell. The basic of CAR-T therapy is tumor specific antigen, this review summarizes related potential tumor antigens in leukemia for CAR-T therapy.