Non-Polio Enteroviruses from Acute Flaccid Paralysis Surveillance in Korea, 2012–2019
Open Access
- 5 March 2021
- Vol. 13 (3), 411
- https://doi.org/10.3390/v13030411
Abstract
The risk of polio importation and re-emergence persists since epidemic polio still occurs in some countries, and the resurgence of polio occurring almost 20 years after polio eradication was declared in Asia has been reported. We analyzed the results of acute flaccid paralysis (AFP) surveillance in Korea to assess the quality of AFP surveillance and understand the etiology of non-polio enterovirus (NPEV)-associated central nervous system diseases in a polio-free area. We investigated 637 AFP patients under 15 years of age whose cases were confirmed during 2012–2019 by virus isolation, real-time reverse transcription polymerase chain reaction, and VP1 gene sequencing. Among the 637 AFP cases, NPEV was detected in 213 (33.4%) patients, with the majority observed in EV-A71, with 54.9% of NPEV positives. EV-A71 has been shown to play a role as a major causative agent in most neurological diseases except for Guillain-Barré syndrome (GBS), acute disseminated encephalomyelitis (ADEM), and meningitis. This study provides information on the AFP surveillance situation in Korea and highlights the polio eradication stage in the monitoring and characterization of NPEV against the outbreak of neurological infectious diseases such as polio.Keywords
Funding Information
- Korea Disease Control and Prevention Agency (4800-4859-300)
This publication has 27 references indexed in Scilit:
- Non‐polio Enterovirus detection with acute flaccid paralysis: A systematic reviewJournal of Medical Virology, 2017
- Impact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine developmentVirology, 2017
- The critical role of acute flaccid paralysis surveillance in the Global Polio Eradication InitiativeInternational Health, 2017
- Genetic changes found in a distinct clade of Enterovirus D68 associated with paralysis during the 2014 outbreakVirus Evolution, 2016
- A national cross-sectional study for poliovirus seroprevalence in the Republic of Korea in 2012: implication for deficiency in immunity to polio among middle-aged peopleBMC Infectious Diseases, 2015
- [Genetic evidence for recombination and mutation in the emergence of human enterovirus 71].2014
- Clinical and enterovirus findings associated with acute flaccid paralysis in the republic of Korea during the recent decadeJournal of Medical Virology, 2013
- Comparative Estimation of Coverage between National Immunization Program Vaccines and Non-NIP Vaccines in KoreaJournal of Korean Medical Science, 2013
- National Action Plan for Response to Poliovirus ImportationOsong Public Health and Research Perspectives, 2011