ADRB2, ADRB3, BDKRB2 and MTNR1B Genes Related to Body fat Modulation and Its Interaction with Physical Activity and Blood Pressure
Open Access
- 1 January 2015
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Open Journal of Endocrine and Metabolic Diseases
- Vol. 05 (07), 88-97
- https://doi.org/10.4236/ojemd.2015.57012
Abstract
Hypertension (HTN) is the risk factor that most contributes to mortality rates in the world, followed by physical inactivity and obesity. Despite the influence of genetic factors on the genesis of HTN, blood pressure levels are strongly influenced by environmental factors such as physical inactivity and overweight, characterizing it as a polygenic disease. Genetic components and environmental factors such as physical exercise may modulate the phenotype of individuals predisposed to medical conditions such as HTN, independently of modifiable factors such as increased levels of adiposity; however, studies have shown that polymorphic forms detected in genes involved in the mechanisms of blood pressure regulation and also related to body fat modulation may interact with physical activity levels and HTN. The aim of this article is to review the interactions between polymorphisms in ADRB2, ADRB3, BDKRB2 and MTNR1B genes, physical activity and blood pressure.Keywords
This publication has 55 references indexed in Scilit:
- Association between the Melatonin Receptor 1B Gene Polymorphism on the Risk of Type 2 Diabetes, Impaired Glucose Regulation: A Meta-AnalysisPLOS ONE, 2012
- Bradykinin β2 Receptor −58T/C Gene Polymorphism and Essential Hypertension: A Meta-AnalysisPLOS ONE, 2012
- Contributions of Renin-Angiotensin System-Related Gene Interactions to Obesity in a Chinese PopulationPLOS ONE, 2012
- Correlates of physical activity: why are some people physically active and others not?The Lancet, 2012
- Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancyThe Lancet, 2012
- The ACE Gene and Human PerformanceSports Medicine, 2011
- Genomewide Association Studies and Assessment of the Risk of DiseaseThe New England Journal of Medicine, 2010
- Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and MelanocortinsJournal of Biological Chemistry, 2010
- Global burden of obesity in 2005 and projections to 2030International Journal of Obesity, 2008
- Genetics of β2-Adrenergic Receptors and the Cardiopulmonary Response to ExerciseExercise and Sport Sciences Reviews, 2008