A 5-Year Review of Senecavirus A in China since Its Emergence in 2015
Open Access
- 30 September 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Veterinary Science
- Vol. 7, 567792
- https://doi.org/10.3389/fvets.2020.567792
Abstract
Senecavirus A (SVA), previously known as Seneca Valley virus, is classified into the genusSenecavirusin the familyPicornaviridae. This virus can cause vesicular disease and epidemic transient neonatal losses in swine. Typical clinical signs include vesicular and/or ulcerative lesions on the snout, oral mucosa, coronary bands and hooves. SVA emerged in Guangdong Province of China in 2015, and thereafter gradually spread into other provinces, autonomous regions and municipalities (P.A.M.s). Nowadays more than half of the P.A.M.s have been affected by SVA, and asymptomatic infection has occurred in some areas. The phylogenetic analysis shows that China isolates are clustered into five genetic branches, implying a fast evolutionary speed since SVA emergence in 2015. This review presented current knowledge concerning SVA infection in China, including its history, epidemiology, evolutionary characteristics, diagnostics and vaccines.Funding Information
- National Science and Technology Planning Project
- Key Technology Research and Development Program of Shandong
This publication has 58 references indexed in Scilit:
- Identification and Complete Genome of Seneca Valley Virus in Vesicular Fluid and Sera of Pigs Affected with Idiopathic Vesicular Disease, BrazilTransboundary and Emerging Diseases, 2015
- Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunityJournal of General Virology, 2014
- Seneca Valley Virus and Vesicular Lesions in a Pig with Idiopathic Vesicular DiseaseJournal of Veterinary Science & Technology, 2012
- Generation and diagnostic application of monoclonal antibodies against Seneca Valley virusJournal of Veterinary Diagnostic Investigation, 2011
- Structural Features of the Seneca Valley Virus Internal Ribosome Entry Site (IRES) Element: a Picornavirus with a Pestivirus-Like IRESJournal of Virology, 2011
- Recombination among picornavirusesReviews in Medical Virology, 2010
- Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirusJournal of General Virology, 2008
- Treatment of Invasive Retinoblastoma in a Murine Model Using an Oncolytic PicornavirusCancer Research, 2007
- Seneca Valley Virus, a Systemically Deliverable Oncolytic Picornavirus, and the Treatment of Neuroendocrine CancersJNCI Journal of the National Cancer Institute, 2007
- A Distinct Group of Hepacivirus/Pestivirus-Like Internal Ribosomal Entry Sites in Members of DiversePicornavirusGenera: Evidence for Modular Exchange of Functional Noncoding RNA Elements by RecombinationJournal of Virology, 2007