Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
Open Access
- 22 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-6
- https://doi.org/10.1038/s41598-021-81370-w
Abstract
An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.Funding Information
- National Natural Science Foundation of China (No. 21702121)
- the 111 Project (D20015)
- Open fund from Hubei Key Laboratory of Natural Products Research and Development of China Three Gorges University (No. NPRD-2018010)
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