Stunting in infancy, pubertal trajectories and adult body composition: the Birth to Twenty Plus cohort, South Africa
Open Access
- 14 August 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Nutrition
- Vol. 75 (1), 189-197
- https://doi.org/10.1038/s41430-020-00716-1
Abstract
Background/objectives Childhood rapid growth and earlier puberty onset have been associated with adult obesity. However, the association between childhood stunting, pubertal timing and adult obesity is unclear. We examined whether the relationship between stunting at age 2 years (y) and body composition at 23 years is mediated by adolescent body mass index, and pubertal development, using the Birth-to-Twenty Plus cohort (South Africa). Subjects/methods For 1036 participants, data on anthropometrics between birth and 23 years, maternal factors, and pubertal development (Tanner scale at 9–16 years) were collected. Stunting at 2 years (height-for-age z-score < −2), 5–18 years BMI-for-age trajectories, pubertal development trajectories, and DXA-derived fat mass (FM) and fat free mass (FFM) at 23 years were determined. Data were analysed using hierarchical regressions and structural equation models. Results Stunting was directly associated with slower pubertal development and with shorter adult stature, but was not associated with adolescent BMI trajectories, adult FM or FFM. However, stunting was indirectly associated with adult FM and FFM through the direct associations between slower pubertal development and lower FM and between shorter height and lower FFM. BMI trajectories were independently associated with FM and FFM. Conclusions Being stunted in this population predicted adult body composition through slower pubertal development and shorter adult stature.Funding Information
- Wellcome Trust (214205/Z/18/Z)
This publication has 51 references indexed in Scilit:
- Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income: findings from five birth cohort studiesThe Lancet, 2013
- Sodium Selenite Improves Folliculogenesis in Radiation-Induced Ovarian Failure: A Mechanistic ApproachPLOS ONE, 2012
- Association between infant nutrition and anthropometry, and pre-pubertal body composition in urban South African childrenJournal of Developmental Origins of Health and Disease, 2012
- Fat free mass explains the relationship between stunting and energy expenditure in urban Mexican Maya childrenAnnals of Human Biology, 2012
- Is Overweight in Stunted Preschool Children in Cameroon Related to Reductions in Fat Oxidation, Resting Energy Expenditure and Physical Activity?PLOS ONE, 2012
- Stunting and obesity in childhood: a reassessment using longitudinal data from South AfricaInternational Journal of Epidemiology, 2012
- Birth weight, postnatal weight gain, and adult body composition in five low and middle income countriesAmerican Journal of Human Biology, 2011
- Growth patterns in early childhood and final attained stature: Data from five birth cohorts from low‐ and middle‐income countriesAmerican Journal of Human Biology, 2010
- Evaluation of DXA against the four-component model of body composition in obese children and adolescents aged 5–21 yearsInternational Journal of Obesity, 2010
- Cohort Profile: Mandela's children: The 1990 birth to twenty study in South AfricaInternational Journal of Epidemiology, 2007