Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction
Open Access
- 30 June 2016
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 7 (2), 152-155
- https://doi.org/10.5155/eurjchem.7.2.152-155.1403
Abstract
A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques.Keywords
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