In 2019 the number of people with TB (Tuberculosis) in Banyumas, Central Java, is high (1,910 people have been detected with TB). The number of people infected Tuberculosis (TB) in Banyumas is the count data and it is also the area data. In modeling, the parameter estimation and characteristic of the data need to be considered. Here, we studied comparing Generalized Poisson (GP), negative binomial (NB), and Poisson and CAR.BYM model for TB cases in Banyumas. Here, we use two methods for parameter estimation, maximum likelihood estimation (MLE) and Bayes. The MLE is used for GP and NB models, whereas Bayes is used for Poisson and CAR-BYM. The results showed that Poisson model detected overdispersion where deviance value is 67.38 for 22 degrees of freedom. Therefore, ratio of deviance to degrees of freedom is 3.06 (>1). This indicates that there was overdispersion. The folowing GP, NB, Poisson-Bayes and CAR-BYM are used to modeling TB data in Banyumas and we compare their RMSE. With refer to RMES criteria, we found that CAR-BYM is the best model for modeling TB in Banyumas because its RMSE is smallest.