Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation
Open Access
- 8 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 56 (6), 1381-1390
- https://doi.org/10.1038/s41409-020-01185-7
Abstract
The aim of this multicentre, longitudinal study was to determine salivary changes in relation to oral mucositis (OM) in multiple myeloma patients following high-dose melphalan and autologous hematopoietic stem cell transplantation (ASCT). Unstimulated and stimulated whole-mouth saliva samples (UWS and SWS) were collected before ASCT, 1×/wk during the hospitalisation phase, and 3 and 12 months post-ASCT. During the hospitalisation period OM was scored 3×/wk (WHO system). Flow rate, pH, total protein concentration (Nanodrop), albumin, lactoferrin, neutrophil defensin-1 (HNP1), total IgA and S100A8/A9 (ELISA) were determined. Mixed models were used to evaluate differences between ulcerative (u)OM (≥2 WHO, n = 20) and non-uOM (n = 31) groups. Until 18 days after ASCT, flow rate, pH, total IgA and HNP1 levels decreased in UWS and/or SWS, while log lactoferrin levels were significantly increased (UWS: p = 0.016 95% CI [0.36, 3.58], SWS: p < 0.001 95% CI [1.14, 3.29]). Twelve months post-ASCT, salivary protein levels were similar to baseline except for log total IgA, which was higher (UWS: p < 0.001 95% CI [0.49, 1.29], SWS: p < 0.001 95% CI [0.72, 1.45]). No differences between uOM and non-uOM groups were observed. Changes in salivary proteins indicated an inflammatory reaction in salivary glands coinciding with mucosal and systemic reactions in response to high-dose melphalan.Keywords
This publication has 40 references indexed in Scilit:
- A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of lifeSupportive Care in Cancer, 2010
- Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11)BMC Medicine, 2009
- The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancerJournal of Leukocyte Biology, 2009
- Oral integrity and salivary profile in myeloma patients undergoing high-dose therapy followed by autologous SCTBone Marrow Transplantation, 2008
- Do Salivary Antibodies Reliably Reflect Both Mucosal and Systemic Immunity?Annals of the New York Academy of Sciences, 2007
- Changes in salivary proteome following allogeneic hematopoietic stem cell transplantationExperimental Hematology, 2007
- Lactoferrin in Sjögren's SyndromeArthritis & Rheumatism, 1984
- Changes in lactoferrin and other proteins in a case of chronic recurrent parotitisJournal of Oral Pathology & Medicine, 1978
- Alterations in Lactoferrin in Salivary Gland DiseaseJournal of Dental Research, 1978