Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients
- 19 April 2021
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 65 (5)
- https://doi.org/10.1128/aac.02504-20
Abstract
Linezolid is an oxazolidinone antibiotic exhibiting efficacy against multidrug-resistant (MDR) Gram-positive-related infections. However, its population pharmacokinetic (PopPK) profile in critically ill Chinese children has not been characterized.Funding Information
- Clinical Pharmacy Research Project of Beijing Pharmaceutical Association (2020)
- Beijing Municipal Administration of Hospitals | Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201813)
This publication has 23 references indexed in Scilit:
- Population Pharmacokinetic Analysis of Linezolid in Low Body Weight Patients with Renal DysfunctionThe Journal of Clinical Pharmacology, 2013
- Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patientsJournal of Antimicrobial Chemotherapy, 2012
- Population Pharmacokinetic and Pharmacodynamic Analysis of Linezolid and a Hematologic Side Effect, Thrombocytopenia, in Japanese PatientsAntimicrobial Agents and Chemotherapy, 2011
- Population Pharmacokinetic Analysis of Linezolid in Patients With Infectious Disease: Application to Lower Body Weight and Elderly PatientsThe Journal of Clinical Pharmacology, 2009
- Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic PatientsDrug Metabolism and Disposition, 2007
- Absolute Bioavailability and Pharmacokinetics of Linezolid in Hospitalized Patients Given Enteral FeedingsAntimicrobial Agents and Chemotherapy, 2005
- Pharmacokinetic studies of linezolid and teicoplanin in the critically illJournal of Antimicrobial Chemotherapy, 2005
- Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulationThe Pediatric Infectious Disease Journal, 2003
- Population Pharmacokinetics of Linezolid in Patients Treated in a Compassionate-Use ProgramAntimicrobial Agents and Chemotherapy, 2003
- Clinical Pharmacodynamics of Linezolid in Seriously Ill Patients Treated in a Compassionate Use ProgrammeClinical Pharmacokinetics, 2003