Facile Preparation of 1-Hydroxy-1,2-Benziodoxol-3(1h)-one 1-Oxide (IBX) and Dess–Martin Reagent Using Sodium Hypochlorite under Carbon Dioxide
- 1 January 2021
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 103 (2), 694-698
- https://doi.org/10.3987/com-20-s(k)66
Abstract
We have developed a safe, convenient, and inexpensive method for preparation of the widely used oxidizing agent 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (IBX), by treatment of 2-iodobenzoic acid with aqueous sodium hypochlorite under CO2 at room temperature. As the only by-product is NaCl, this reaction can be utilized for one-pot synthesis of 1,1,1-triacetoxy-1,2-benziodoxol-3(1H)-one (Dess-Martin reagent) in excellent yield.Keywords
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