Poly(2‐ethyl‐2‐oxazoline) Featuring a Central Amino Moiety
Open Access
- 7 May 2021
- journal article
- research article
- Published by Wiley in Macromolecular Rapid Communications
- Vol. 42 (13), 2100132
- https://doi.org/10.1002/marc.202100132
Abstract
The incorporation of an amino group into a bifunctional initiator for the cationic ring‐opening polymerization (CROP) is achieved in a two‐step reaction. Detailed kinetic studies using 2‐ethyl‐2‐oxazoline demonstrate the initiators’ eligibility for the CROP yielding well‐defined polymers featuring molar masses of about 2000 g mol–1. Deprotection of the phthalimide moiety subsequent to polymerization enables the introduction of a cyclooctyne group in central position of the polymer which is further exploited in a strain‐promoted alkyne‐azide click reaction (SpAAC) with a Fmoc‐protected azido lysine representing a commonly used binding motif for site specific polymer–protein/peptide conjugation. In‐depth characterization via electrospray ionization mass spectrometry (ESI) confirms the success of all post polymerization modification steps.Keywords
Funding Information
- Thüringer Aufbaubank (2016 IZN 0009)
- Deutsche Forschungsgemeinschaft (316213987)
- Bundesministerium für Bildung und Forschung (13XP5049C)
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