Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot
Open Access
- 19 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 12 (13), 4789-4793
- https://doi.org/10.1039/d0sc06264b
Abstract
N-Substituted tetrahydroquinoxalines (37 examples) were step-economically obtained in good yield (<97%) and ee (<99%) with readily available substrates. The reaction proceeds through an interesting regioselective Heyns rearrangement/enantioselective transfer hydrogenation in one pot. The substrate scope and the reaction mechanism were systematically investigated.Keywords
Funding Information
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018402)
- West Light Foundation of the Chinese Academy of Sciences (25E0C304)
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