Crosstalk between maternal perinatal obesity and offspring dopaminergic circuitry
- 30 June 2020
- journal article
- editorial
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 130 (7), 3416-3418
- https://doi.org/10.1172/JCI138123
Abstract
The mechanism by which maternal obesity influences fetal brain development and behavior is not well understood. In this issue of the JCI, Lippert et al. showed that feeding maternal mice a high-fat diet (HFD) during lactation attenuated the activity of dopamine (DA) midbrain neurons and altered the DA-related behavioral phenotype seen in the offspring. The authors further suggested that the altered excitatory and inhibitory balance between D1 medium spiny neurons (MSN) and D2 MSN mediates this behavioral phenotype. These mechanisms may provide strategies for preventing the negative effects of maternal obesity on offspring development and adult health.This publication has 17 references indexed in Scilit:
- Maternal Body Mass Index and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysisScientific Reports, 2016
- The role of maternal obesity in the risk of neuropsychiatric disordersFrontiers in Neuroscience, 2015
- Maternal immune activation and abnormal brain development across CNS disordersNature Reviews Neurology, 2014
- Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feedingMolecular Psychiatry, 2014
- Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat FeedingCell, 2014
- Dopamine Signaling in reward-related behaviorsFrontiers in Neural Circuits, 2013
- AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviorsNature Neuroscience, 2012
- Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesityWires Systems Biology and Medicine, 2010
- Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administrationPsychopharmacology, 2007
- Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetiteJCI Insight, 2006