Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
Open Access
- 28 January 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in Open Forum Infectious Diseases
- Vol. 8 (3), ofab043
- https://doi.org/10.1093/ofid/ofab043
Abstract
A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training.Funding Information
- Genome British Columbia
This publication has 5 references indexed in Scilit:
- Serological survey following SARS-COV-2 outbreaks at long-term care facilities in metro Vancouver, British Columbia: Implications for outbreak management and infection control policiesAmerican Journal of Infection Control, 2020
- Evaluation of Six Commercial Mid- to High-Volume Antibody and Six Point-of-Care Lateral Flow Assays for Detection of SARS-CoV-2 AntibodiesJournal of Clinical Microbiology, 2020
- Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence surveyThorax, 2020
- Four point-of-care lateral flow immunoassays for diagnosis of COVID-19 and for assessing dynamics of antibody responses to SARS-CoV-2Journal of Infection, 2020
- Real-time PCR-based SARS-CoV-2 detection in Canadian laboratoriesJournal of Clinical Virology, 2020