Prognostic factors affecting survival in children and adolescents with HIV and Hodgkin lymphoma in South Africa
- 7 December 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Leukemia & Lymphoma
- Vol. 62 (12), 2854-2863
- https://doi.org/10.1080/10428194.2020.1852472
Abstract
South African children with Hodgkin lymphoma (HL) and human immunodeficiency virus (HIV) have low 5-year overall survival (OS) rates. In this retrospective multicenter study, 271 South African pediatric patients with HL were studied to determine OS and prognostic factors in those with HIV and HL. Univariate risk factor analysis was performed to analyze prognostic factors. The 29 HIV-infected patients were younger (p = .021), more likely to present with wasting (0.0573), stunting (0.0332), and Stage IV disease (p = .000) than HIV-uninfected patients. The 5- and 10-year OS of HIV-infected patients of 49% and 45% versus 84% and 79%, respectively for HIV-uninfected patients (p = .0001) appeared to be associated with hypoalbuminemia (<20 g/dL) and CD4 percentage of <15%. Causes of death in the HIV-infected group included disease progression (6/14), infection (4/14), unknown (3/14), and second malignancy (1/14). HIV-infected pediatric patients with HL experience increased mortality due to post-therapy opportunistic and nosocomial infections.This publication has 25 references indexed in Scilit:
- Health in South Africa: changes and challenges since 2009The Lancet, 2012
- Stage-Adapted Treatment of HIV-Associated Hodgkin Lymphoma: Results of a Prospective Multicenter StudyJournal of Clinical Oncology, 2012
- Long-term Cancer Risk among People Diagnosed with AIDS during ChildhoodCancer Epidemiology, Biomarkers & Prevention, 2012
- BEACOPP chemotherapy is a highly effective regimen in children and adolescents with high-risk Hodgkin lymphoma: a report from the Children's Oncology GroupBlood, 2011
- A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425Blood, 2009
- The demographic impact of HIV and AIDS across the family and household life-cycle: implications for efforts to strengthen families in sub-Saharan AfricaAIDS Care, 2009
- Cancer Rates After Year 2000 Significantly Decrease in Children With Perinatal HIV Infection: A Study by the Italian Register for HIV Infection in ChildrenJournal of Clinical Oncology, 2007
- Spectrum of cancers among HIV‐infected persons in Africa: The Uganda AIDS‐Cancer Registry Match StudyInternational Journal of Cancer, 2005
- Child mortality in relation to HIV infection, nutritional status, and socio-economic backgroundInternational Journal of Epidemiology, 2004
- Infection prevention strategies for children with cancer and AIDS: contrasting dilemmasJournal of Hospital Infection, 1995