Amphiphilic Au Nanoclusters Modulated by Magnetic Gemini Surfactants as a Cysteine Chemosensor and an MRI Contrast Agent
- 3 March 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 37 (10), 3130-3138
- https://doi.org/10.1021/acs.langmuir.0c03618
Abstract
Cationic magnetic Gemini surfactants (mag-G-surfs ), [C14H29(CH3)(2)N(CH2)(2)N(CH3)(2)C14H292+center dot 2[XCl3Br](-) (14-2-14.2X, X = Ce, Gd, or Ho), efficiently induce the aggregation of glutathione-protected Au nanoclusters (NCs) (GSH-Au NCs). These magnetic luminescent aggregates not only possess aggregation-induced emission (AIE) behavior but also display aggregation-induced magnetic enhancement. In particular, 14-2-14.2Ce and 14-2-14.2Gd have a better effect on boosting the luminescence intensity, quantum yield (QY), and luminescence lifetime (tau). The luminescent aggregates of GSH-Au NCs triggered by 14-2-14.2Gd or 14-2-14.2Ho exhibit more favorable paramagnetic behavior. Other Au NCs containing a Au(I)-thiolate complex shell also exhibit the obvious AIE phenomenon after introducing 14-2-14.2Gd, demonstrating the luminescence enhancement effect of mag-G-surfs. The luminescent aggregate 14-2-14.2Ce@GSH-Au NCs can serve as a "light up" fluorometric probe to detect cysteine selectively with the detection limit (DL) of 36 mu M, and the magnetic luminescent aggregate 14-2-14.2Gd@GSH-Au NCs has the potential to be a novel contrast agent in T-1-weighted magnetic resonance (MR) imaging due to its satisfactory contrasting ability.Keywords
Funding Information
- National Natural Science Foundation of China (22032003, 22072073)
- Natural Science Foundation of Shandong Province (ZR2018ZA0547)
This publication has 47 references indexed in Scilit:
- Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgensChemical Science, 2020
- Gold nanoclusters for ratiometric sensing of pH in extremely acidic mediaChemical Communications, 2019
- Gold-Nanocluster-Embedded Mucin Nanoparticles for Photodynamic Therapy and BioimagingLangmuir, 2019
- Self-assembled gold nanoclusters for fluorescence turn-on and colorimetric dual-readout detection of alkaline phosphatase activity via DCIP-mediated fluorescence resonance energy transferTalanta, 2018
- Plant Protein-Directed Synthesis of Luminescent Gold Nanocluster Hybrids for Tumor ImagingACS Applied Materials & Interfaces, 2017
- Atomically Precise Clusters of Noble Metals: Emerging Link between Atoms and NanoparticlesChemical Reviews, 2017
- Recent advances in biomedical applications of fluorescent gold nanoclustersAdvances in Colloid and Interface Science, 2017
- Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and OpportunitiesChemical Reviews, 2016
- Atomically precise metal nanoclusters: stable sizes and optical propertiesNanoscale, 2014
- Functionalized Quantum Dots for Biosensing and Bioimaging and Concerns on ToxicityACS Applied Materials & Interfaces, 2013