NMDAR Hypofunction Animal Models of Schizophrenia
Open Access
- 31 July 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Molecular Neuroscience
- Vol. 12, 185
- https://doi.org/10.3389/fnmol.2019.00185
Abstract
The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to help understand the etiology and pathophysiology of schizophrenia. This hypothesis was based on early observations that NMDAR antagonists could induce a full range of symptoms of schizophrenia in normal human subjects. Accumulating evidence in humans and animal studies points to NMDAR hypofunctionality as a convergence point for various symptoms of schizophrenia. Here we review animal models of NMDAR hypofunction generated by pharmacological and genetic approaches, and how they relate to the pathophysiology of schizophrenia. In addition, we discuss the limitations of animal models of NMDAR hypofunction and their potential utility for therapeutic applications.Keywords
Funding Information
- National Institute of Mental Health (MH115188A)
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