Estimates of beta cell function adjusted by anthropometric markers in patients with T2DM
- 15 May 2020
- journal article
- research article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 47 (9), 1509-1516
- https://doi.org/10.1111/1440-1681.13337
Abstract
We sought to determine whether adjusting the indices used to assess beta cell function by anthropometric markers of obesity improves their clinical value in a diabetic population. We conducted a cross‐sectional survey of 3,732 diabetic patients who underwent a 100 gram carbohydrate‐meal test. Insulin secretion was estimated using HOMA‐B of steady state as well as △C0‐30/△G0‐30, △AUCc30‐120/△AUCG30‐120 and CPIn for dynamic state. Body weight index, waist circumference, waist‐hip ratio and body surface area were recorded. The final analysis included 2,873 T2DM patients. Correlation analyses showed that there was a poor correlation between diabetic duration and CPI30 (r=‐0.040, P30 was divided by BMI, WC, WHR, or body surface area, respectively. The same was found for the correlation between HbA1c and CPI120 with these measures. The main determinants of diabetic duration were age (β=0.388, PP30 (β=‐0.045, P=0.011). There were no remarkable changes in β weights between diabetic duration and CPI30 when it was corrected with anthropometric markers in the multiple stepwise linear regression analyses. The same was found between HbA1c and CPI120. CPI30 and CPI120 are more practical indexes. Correcting the indices used to estimate the beta cell function by anthropometric markers of obesity may not improve their correlations with diabetic duration or HbA1c in a diabetic population.Keywords
This publication has 24 references indexed in Scilit:
- Adipocyte lipolysis and insulin resistanceBiochimie, 2015
- Assessment of Pancreatic β-Cell Function: Review of Methods and Clinical ApplicationsCurrent Diabetes Reviews, 2014
- Prevalence and Control of Diabetes in Chinese AdultsJAMA, 2013
- Effects of Rosiglitazone, Glyburide, and Metformin on β-Cell Function and Insulin Sensitivity in ADOPTDiabetes, 2011
- Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose LevelsDiabetes Care, 2009
- Glycemic Durability of Rosiglitazone, Metformin, or Glyburide MonotherapyNew England Journal of Medicine, 2006
- Use and Abuse of HOMA ModelingDiabetes Care, 2004
- Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)The Lancet, 1998
- In Praise of the Hyperglycemic Clamp: A method for assessment of β-cell sensitivity and insulin resistanceDiabetes Care, 1996
- U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive DiseaseDiabetes, 1995