Drug-Induced Anaphylaxis: An Update on Epidemiology and Risk Factors
Open Access
- 12 May 2020
- journal article
- review article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 181 (7), 481-487
- https://doi.org/10.1159/000507445
Abstract
Drug hypersensitivity is one of the most frequent causes of anaphylaxis, particularly in adults and in hospitalized patients. Drug-induced anaphylaxis (DIA) is also associated with more severe outcomes than other anaphylaxis triggers, and drugs are responsible for the majority of deaths due to anaphylaxis. We here review the current knowledge on the incidence, prevalence, drugs involved, mortality, and mortality risk factors for DIA. The incidence of both anaphylaxis and DIA seems to be increasing worldwide. Antibiotics and analgesics are the most frequently reported triggers of DIA. However, the importance of other drug groups should be taken into account, especially in particular settings (e.g., peri-operative and oncology). The identification of risk factors, geographical variables, and drugs associated with higher risk for DIA may improve the outcomes of this entity.Keywords
This publication has 43 references indexed in Scilit:
- 2012 UpdateCurrent Opinion in Allergy and Clinical Immunology, 2012
- Drug allergy in mast cell diseaseCurrent Opinion in Allergy and Clinical Immunology, 2012
- Perioperative AnaphylaxisMedical Clinics of North America, 2010
- Anaphylaxis epidemiology in patients with and patients without asthma: A United Kingdom database reviewJournal of Allergy and Clinical Immunology, 2010
- Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactionsJournal of Allergy and Clinical Immunology, 2010
- Anaphylaxis fatalities and admissions in AustraliaJournal of Allergy and Clinical Immunology, 2009
- Allergy and the cardiovascular systemClinical and Experimental Immunology, 2008
- Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005Journal of Allergy and Clinical Immunology, 2007
- Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working GroupAnnals of Allergy, Asthma & Immunology, 2006
- Anaphylaxis: can we tell who is at risk of a fatal reaction?Current Opinion in Allergy and Clinical Immunology, 2004