ACQ-to-AIE Transformation: Tuning Molecular Packing by Regioisomerization for Two-Photon NIR Bioimaging
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- 27 July 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 59 (31), 12822-12826
- https://doi.org/10.1002/anie.202005785
Abstract
The traditional design strategies for highly bright solid-state luminescent materials rely on weakening the intermolecular pi-pi interactions, which may limit diversity when developing new materials. Herein, we propose a strategy of tuning the molecular packing mode by regioisomerization to regulate the solid-state fluorescence. TBP-e-TPA with a molecular rotor in the end position of a planar core adopts a long-range cofacial packing mode, which in the solid state is almost non-emissive. By shifting molecular rotors to the bay position, the resultant TBP-b-TPA possesses a discrete cross packing mode, giving a quantum yield of 15.6 +/- 0.2 %. These results demonstrate the relationship between the solid-state fluorescence efficiency and the molecule's packing mode. Thanks to the good photophysical properties, TBP-b-TPA nanoparticles were used for two-photon deep brain imaging. This molecular design philosophy provides a new way of designing highly bright solid-state fluorophores.Funding Information
- National Natural Science Foundation of China (51903052)
- National Natural Science Foundation of China (21788102, 21805002, 61735016 and 61975172)
- Innovation and Technology Commission (ITC-CNERC14SC01 and ITCPD/17-9)
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