Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses
Open Access
- 18 February 2021
- journal article
- research article
- Published by eLife Sciences Publications, Ltd in eLife
Abstract
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of the immune and nervous system processes in a nonhuman primate model of West Nile virus neurological disease, we show that virus infection disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with distinct functions in each component of the axis. This pleiotropic gene regulation suggests an unintended off-target negative impact of virus-induced host immune responses on the neurotransmission, which may be a common feature of various viral infections of the CNS.Funding Information
- National Institute of Allergy and Infectious Diseases (Intramural Research Program)
This publication has 76 references indexed in Scilit:
- Innate immunity in the central nervous systemJCI Insight, 2012
- Gene Expression Analysis in the Thalamus and Cerebrum of Horses Experimentally Infected with West Nile VirusPLOS ONE, 2011
- Nonhuman Primate Models of Human ImmunologyAntioxidants and Redox Signaling, 2011
- Immune Response to the West Nile Virus in Aged Non-Human PrimatesPLOS ONE, 2010
- Regulation of synaptic connectivity by gliaNature, 2010
- Cellular Inflammatory Response to Flaviviruses in the Central Nervous System of a Primate HostJournal of Histochemistry & Cytochemistry, 2009
- Single proteins might have dual but related functions in intracellular and extracellular microenvironmentsNature Reviews Molecular Cell Biology, 2009
- Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman PrimatesJournal of Virology, 2008
- PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesNature Genetics, 2003
- Gene Expression Omnibus: NCBI gene expression and hybridization array data repositoryNucleic Acids Research, 2002