Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
Open Access
- 1 January 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Therapeutics and Clinical Risk Management
- Vol. ume 17, 65-71
- https://doi.org/10.2147/tcrm.s282840
Abstract
Aim: To explore the growth-promoting effect of vacuum sealing drainage (VSD) during the healing processes of diabetic foot ulcers (DFUs). Methods: From November 2018 to December 2019, 38 patients with unilateral DFUs were enrolled in this retrospective study. All patients were divided into two groups according to the use of VSD or not: the VSD group (n=20) and the control group (n=18). The following parameters were used to evaluate the healing process: changes in the mean areas of the ulcers; healing rate (HR); epithelial hyperplasia and angiogenesis as determined by hematoxylin-eosin staining (HE staining); and expression of CD34, CD68 and VEGF as assessed through immunohistochemistry. Perioperative side effects and complications were also recorded. Results: All patients received follow-up and eventually healed. The mean area of wounds was reduced in the VSD group compared to the control group (1.75± 0.64 cm2 vs 0.88± 0.54 cm2, P=0.031). The mean HR of the ulcers in the VSD group was significantly higher than that in the control group (35.23± 2.87% vs 28.78± 1.09%, P=0.017). HE staining showed that the amount of epithelial hyperplasia and angiogenesis increased significantly after VSD, and the immunohistochemistry results showed that the expression of CD34, CD68 and VEGF increased significantly in the VSD group. Conclusion: VSD could significantly accelerate the wound healing process, probably by enhancing the inflammatory response and promoting granulation and angiogenesis in DFUs.Keywords
This publication has 27 references indexed in Scilit:
- Effectiveness and safety of elective surgical procedures to improve wound healing and reduce re‐ulceration in diabetic patients with foot ulcersDiabetes/Metabolism Research and Reviews, 2012
- VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylationMolecular Biology of the Cell, 2011
- Angiogenesis in Wounds Treated by Microdeformational Wound TherapyAnnals of Surgery, 2011
- Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent modelJournal of Plastic, Reconstructive & Aesthetic Surgery, 2009
- Macrophage activation and polarizationFrontiers in Bioscience-Landmark, 2008
- Cellular and molecular basis of wound healing in diabetesJCI Insight, 2007
- Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound HealingThe American Journal of Pathology, 2007
- Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trialThe Lancet, 2005
- Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrixMicroscopy Research and Technique, 2002
- Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites FluidScience, 1983