Clocks, cancer, and chronochemotherapy
Top Cited Papers
- 1 January 2021
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 371 (6524), 42-+
- https://doi.org/10.1126/science.abb0738
Abstract
The circadian clock coordinates daily rhythmicity of biochemical, physiologic, and behavioral functions in humans. Gene expression, cell division, and DNA repair are modulated by the clock, which gives rise to the hypothesis that clock dysfunction may predispose individuals to cancer. Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis and progression of tumors, available data are insufficient to conclude that clock disruption is generally carcinogenic. Similarly, studies have suggested a circadian time-dependent efficacy of chemotherapy, but clinical trials of chronochemotherapy have not demonstrated improved outcomes compared with conventional regimens. Future hypothesis-driven and discovery-oriented research should focus on specific interactions between clock components and carcinogenic mechanisms to realize the full clinical potential of the relationship between clocks and cancer.Keywords
Funding Information
- National Institutes of Health (GM118102)
- National Institutes of Health (ES027255)
- National Institutes of Health (EY023937)
- National Institutes of Health (EY026921)
- Research to Prevent Blindness (Unrestricted Departmental Grant)
- Mark J. Daily, MD Research Fund (N/A)
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