Renal intravascular large B-cell lymphoma predominantly localized in peritubular capillaries
- 3 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in CEN Case Reports
- Vol. 10 (3), 1-5
- https://doi.org/10.1007/s13730-020-00570-x
Abstract
We report on a 70-year-old woman with intravascular large B-cell lymphoma, in whom the renal lesion was localized in the peritubular capillaries. The patient complained of fatigue, general malaise, and unsteadiness when walking. Laboratory tests showed anemia, increased C-reactive protein, and mild renal failure, with a serum creatinine level of 1.31 mg/dL and no remarkable proteinuria or hematuria. Renal biopsy showed intravascular large B-cell lymphoma. The large atypical cells were mainly accumulated within the peritubular capillaries and no large atypical cells were found in the glomeruli. Skin and bone marrow biopsies confirmed intravascular large B-cell lymphoma. Brain magnetic resonance imaging showed multiple small infarctions in the cerebral white matter. The patient was treated with dexamethasone, methotrexate, and cytarabine followed by CHOP (combined cyclophosphamide, doxorubicin, vincristine, and prednisone) and R-CHOP (CHOP with the recombinant anti-CD20 antibody rituximab), and her renal function improved soon after the start of chemotherapy.Keywords
This publication has 10 references indexed in Scilit:
- Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water DeprivationJournal of the American Society of Nephrology, 2019
- Renal Intravascular Large B-cell Lymphoma: A Case Report and Review of the LiteratureInternal Medicine, 2017
- Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 casesIndian Journal of Nephrology, 2015
- Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and RegenerationDevelopmental Cell, 2013
- Intravascular large B-cell lymphoma of the kidney: A case reportDiagnostic Pathology, 2011
- Expression and Subcellular Distribution of Novel Glomerulus-Associated Proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14RikJournal of the American Society of Nephrology, 2007
- Renal Intravascular Large B-cell Lymphoma Localized Only within Peritubular Capillaries Report of a CaseInternal Medicine, 2007
- Glomerular endothelial cell differentiationKidney International, 2005
- Lymphomas diagnosed by percutaneous kidney biopsyAmerican Journal of Kidney Diseases, 2003
- Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.The Journal of cell biology, 1991