Distinct Associations of Cognitive Impairments and Reduced Gray Matter Volumes in Remitted Patients with Schizophrenia and Bipolar Disorder
Open Access
- 11 December 2020
- journal article
- research article
- Published by Hindawi Limited in Neural Plasticity
- Vol. 2020, 1-9
- https://doi.org/10.1155/2020/8859388
Abstract
Background. Cognitive impairments are documented in schizophrenia (SZ) and bipolar disorder (BD) and may be related to gray matter volumes (GMVs). Thus, this study is aimed at exploring whether the association between cognitive impairments and GMV alterations is similar in patients with SZ and BD and understanding the underlying neurobiological mechanisms. Methods. A total of 137 adult subjects (46 with SZ, 35 with BD, and 56 age-, sex-, and education-matched healthy controls (HC)) completed the MATRICS Consensus Cognitive Battery (MCCB) and structural magnetic resonance imaging scanning. We performed group comparisons of the cognitive impairments, the GMV alterations, and the association between them. Results. Compared with HC, the patients with SZ and BD showed shared deficits in 4 cognitive domains (i.e., processing speed, working memory, problem solving, and social cognition) and the composite. SZ and BD had commonly decreased GMVs, mainly in the insula, superior temporal pole, amygdala, anterior cingulate, and frontal cortices (superior, middle, opercular inferior, and orbital frontal gyrus). No correlation between MCCB scores and GMVs was detected in SZ. However, for BD, working memory was relevant to the right hemisphere (i.e., right insula, amygdala, superior temporal pole, and medial and dorsolateral superior frontal gyrus). Limitations. The major limitations were that not all patients were the first-episode status and no medication. Conclusions. The association was mainly limited to the BD group. Thus, the underlying pathophysiology of the cognitive deficits, in terms of GMV alterations, may be diverse between two disorders.Keywords
Funding Information
- Natural Science Foundation of Liaoning Province (81725005, U1808204, 3110118055, 3110117059, 2019-MS-05, LT2017007, 2016YFC1306900, 2018YFC1311604)
This publication has 55 references indexed in Scilit:
- Cognitive Impairment in Bipolar Disorder and Schizophrenia: A Systematic ReviewAmerican Journal of Translational Research, 2013
- Meta‐analysis of the association between cognitive abilities and everyday functioning in bipolar disorderBipolar Disorders, 2012
- Grey matter differences in bipolar disorder: a meta‐analysis of voxel‐based morphometry studiesBipolar Disorders, 2012
- A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: The Schizo-Bipolar ScaleSchizophrenia Research, 2011
- Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: A matched control studyPsychiatry Research: Neuroimaging, 2011
- The MATRICS Consensus Cognitive Battery in Patients with Bipolar I DisorderNeuropsychopharmacology, 2011
- A fast diffeomorphic image registration algorithmNeuroImage, 2007
- Social cognition and frontal lobe pathology in schizophrenia: A voxel-based morphometric studyNeuroImage, 2007
- Voxel-Based Morphometry—The MethodsNeuroImage, 2000
- A Rating Scale for Mania: Reliability, Validity and SensitivityThe British Journal of Psychiatry, 1978