Human ectopic olfactory receptors and their food originated ligands: a review
- 19 February 2021
- journal article
- review article
- Published by Taylor & Francis Ltd in Critical Reviews in Food Science and Nutrition
- Vol. 62 (20), 5424-5443
- https://doi.org/10.1080/10408398.2021.1885007
Abstract
Ectopic olfactory receptors (EORs) are expressed in non-nasal tissues of human body. They belong to the G-protein coupled receptor (GPCR) superfamily. EORs may not be capable of differentiating odorants as nasal olfactory receptors (ORs), but still can be triggered by odorants and are involved in different biological processes such as anti-inflammation, energy metabolism, apoptosis etc. Consumption of strong flavored foods like celery, oranges, onions, and spices, is a good aid to attenuate inflammation and boost our immune system. During the digestion of these foods in human digestive system and the metabolization by gut microbiota, the odorants closely interacting with EORs, may play important roles in various bio-functions like serotonin release, appetite regulation etc., and ultimately impact health and diseases. Thus, EORs could be a potential target linking the ligands from food and their bioactivities. There have been related studies in different research fields of medicine and physiology, but still no systematic food oriented review. Our review portrays that EORs could be a potential target for functional food development. In this review, we summarized the EORs found in human tissues, their impacts on health and disease, ligands interacting with EORs exerting specific biological effects, and the mechanisms involved.Keywords
Funding Information
- Beijing Natural Science Foundation (002)
- Natural Science Foundation of China
- Beijing municipal education commission general project
- National Key Research and Development Program of China (801)
- Beijing Excellent Talents Funding for Youth Scientist Innovation Team (3TD01)
- Support Project of High-level Teachers in Beijing Municipal Universities
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