Post-operative agranulocytosis caused by intravenous cefazolin: A case report with a discussion of the pathogenesis
- 18 February 2022
- journal article
- Published by Heighten Science Publications Corporation in Archives of Pathology and Clinical Research
- Vol. 6 (1), 009-012
- https://doi.org/10.29328/journal.apcr.1001030
Abstract
A case of post-operative agranulocytosis which occurred in a 66-year-old woman following surgery for endometrial carcinoma is reported. The agranulocytosis had a rapid onset, being detected on the first post-operative day. The causative agent, cefazolin was given to the patient intraoperatively. The agranulocytosis persisted until the 22nd postoperative day. A bone marrow biopsy performed on post-operative day four showed a left-shifted myeloid maturation pattern but not a maturation arrest. The pathogenesis of drug-induced neutropenia/agranulocytosis is discussed. It is postulated that reversible binding of cefazolin to albumin accounts for the prolonged duration of agranulocytosis.Keywords
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