α-Galactosyl Phytosphingosine 2,6’-Diamide as an Inducer of Invariant Natural Killer T Cell
Open Access
- 1 January 2013
- journal article
- Published by Scientific Research Publishing, Inc. in Open Journal of Medicinal Chemistry
- Vol. 03 (03), 55-59
- https://doi.org/10.4236/ojmc.2013.33008
Abstract
Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.Keywords
This publication has 1 reference indexed in Scilit:
- Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptorsNature Immunology, 2011