Anti-Sickling Propensities of Carica papaya (L) Plants Extracts

Abstract

Sickle cell disease (SCD) is a genetic disorder and the disease is incurable. The management process solely concentrates on providing relief to the patient during the crisis stage of the disease. In this context, phytochemicals present in the plants with antisickling propensities are widely exploited as a cure. Various plants have been reported to possess antisickling propensities by various authors. The present study attempts to investigate in vitro, the antisickling endeavors (sickle cell reversal and erythrocytic inhibition to a sickled contour) of the leaves, seeds and stem extracts of Carica papaya L. in HbSS blood samples, using p-hydroxybenzoic acid and phosphate buffer saline as positive and negative controls. The inhibition and reversal activities for different concentrations viz., 0.1 to 10.0 mg/ml of extracts revealed maximum inhibition activity (IA) of 71.80% in Carica papaya L. leaves in a concentration of 1.0 mg/ml; seeds showed a IA of 68.50% in a concentration of 2.5 mg/ml; while the stems showed a IA of 68.33% in a concentration of 10.0 mg/ml. On the other hand, maximum reversal activity (RA) of 72.43% in Carica papaya L. leaves in a concentration of 10.0 mg/ml; seeds showed a RA of 65.96% in a concentration of 10.0 mg/ml; while the stems showed a RA of 62.97% in a concentration of 10.0 mg/ml.