Phenomic profiling of a novel sibling species within the Scedosporium complex in Thailand
Open Access
- 9 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Microbiology
- Vol. 21 (1), 1-15
- https://doi.org/10.1186/s12866-021-02105-5
Abstract
Background Scedosporium species are a group of pathogenic fungi, which can be found worldwide around high human-impacted areas. Infections of Scedosporium have been reported in several immunocompromised and immunocompetent patients with a high mortality rate. Recently, we have isolated and identified several Scedosporium strains during an environmental survey in Thailand. Results We describe the isolate, TMMI-012, possibly a new species isolated from soils in the Chatuchak public park, Bangkok, Thailand. TMMI-012 is phylogenetically related to the Scedosporium genus and is a sibling to S. boydii but shows distinct morphological and pathological characteristics. It is fast growing and highly resistant to antifungal drugs and abiotic stresses. Pathological studies of in vitro and in vivo models confirm its high virulence and pathogenicity. Conclusion TMMI-012 is considered a putative novel Scedosporium species. The high antifungal resistance of TMMI-012 compared with its sibling, Scedosporium species is likely related to its clinical impact on human health.Keywords
This publication has 67 references indexed in Scilit:
- Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulenceFrontiers in Microbiology, 2013
- Species-Specific Antifungal Susceptibility Patterns of Scedosporium and Pseudallescheria SpeciesAntimicrobial Agents and Chemotherapy, 2012
- Fungal Biofilm ResistanceInternational Journal of Microbiology, 2012
- Identification of Pseudallescheria and Scedosporium Species by Three Molecular MethodsJournal of Clinical Microbiology, 2011
- Chitin synthesis and fungal pathogenesisCurrent Opinion in Microbiology, 2010
- Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidiaBMC Microbiology, 2009
- Molecular and Phenotypic Data Supporting Distinct Species Statuses for Scedosporium apiospermum and Pseudallescheria boydii and the Proposed New Species Scedosporium dehoogiiJournal of Clinical Microbiology, 2008
- Infections Caused byScedosporiumsppClinical Microbiology Reviews, 2008
- Antifungal Susceptibilities of the Species of the Pseudallescheria boydii ComplexAntimicrobial Agents and Chemotherapy, 2006
- Biofilm Formation by the Emerging Fungal Pathogen Trichosporon asahii : Development, Architecture, and Antifungal ResistanceAntimicrobial Agents and Chemotherapy, 2006