Cellulose undergoes hydrolysis utilizing chemicals to deliver glucose, which might be utilized for the production of ethanol, organic acids, and various chemicals. Cellulases are a collection of hydrolytic catalysts that can hydrolyze the most plentiful natural polymer for example cellulose into smaller sugar components including glucose subunits. Cellulase is overpriced and contributes simply half to the general expense of hydrolysis because of the low explicit activity. This enzyme has enormous potential in industries and its use in food, beverages, textile, laundry, paper, and mash industries, and so forth. Consequently, there has been a lot of examination focused on new microorganisms producing cellulose enzymes with higher specific activities and greater efficiency. Currently, work is pointed toward screening and disconnecting cellulolytic growths from the marine samples gathered from the Bay of Bengal, Puri coast, Odisha. All out 7 fungi were isolated from these dirt examples, out of which 2 fungi were portraying the extensive cellulase activity. The fungal isolate, for example, MWF-1 andMSF-6 isolated from water silt respectively were recognized to show the most extreme zone of hydrolysis of carboxy-methyl cellulose. The cellulase activity was assayed by Carboxymethylcellulose "CMCase" (endoglucanase) measure.