Exosomal miR-92a Concentration in the Serum of Shift Workers
Open Access
- 7 January 2020
- journal article
- research article
- Published by MDPI AG in Applied Sciences
- Vol. 10 (2), 430
- https://doi.org/10.3390/app10020430
Abstract
Shift work is associated with alterations in the human biological clock and metabolism. Serum exosomal miR-92a concentration was inversely correlated with brown adipose tissue activity playing a pivotal role in energy balance. In this study, miR-92a was measured in serum exosomes of 30 workers engaged in shift and daytime work. No significant metabolic alterations were shown between daytime and shift workers while a difference in serum exosomal miR-92a levels was found between the two groups. The lower levels of miR-92a in shift workers were suggestive of a higher brown adipose tissue activity compared with daytime workers. However, the possibility that other physiological and pathological processes may influence miR-92a cannot be ruled out. Our results suggest further investigations on brown adipose tissue activity and on miR-92a regulatory mechanisms, such as those related to the estrogen pathway, in shift workers.This publication has 92 references indexed in Scilit:
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