Training of a discrete motor skill in humans is accompanied by increased excitability of the fastest corticospinal connections at movement onset
Open Access
- 1 August 2020
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 598 (16), 3485-3500
- https://doi.org/10.1113/JP279879
Abstract
Key points The primary motor cortex (M1) is fundamentally important for the acquisition of skilled motor behaviours. We tested the excitability changes of distinct M1 circuits at movement onset with TMS H-reflex conditioning. Human subjects trained a discrete spatiotemporal motor skill. Practice was associated with reduced kinematic variability and improved motor performance. Performance improvements were paralleled by task-specific excitability increases of the fastest corticospinal connections at infragranular layer 5b of M1. No task-related changes in excitability were observed at supragranular layers. Excitability changes in the fastest corticospinal connections were not directly related to changes in motor performance. The primary motor cortex (M1) is fundamentally important for the acquisition of skilled motor behaviours. Recent advances in imaging and electrophysiological techniques have improved our understanding of M1 neural circuit modulation in rodents and non-human primates during motor learning. However, little remains known about the learning-related changes of distinct elements in the human brain. In this study, we tested excitability changes of different neural circuits (infragranular and supragranular layers) in the M1 of human subjects who underwent training in a discrete spatiotemporal motor skill. Excitability modulations were assessed by recording H-reflex facilitation from transcranial magnetic stimulation at movement onset. Motor practice improved the consistency of movements and was accompanied by an excitability increase of the fastest corticospinal connections during the initial stages of motor practice. No such excitability changes were observed for training in a simple motor skill and circuits at supragranular layers of M1. Notably, changes in excitability were not associated with changes in motor performance. Our findings could reflect learning-related increases in the recruitment and/or reorganisation of the fastest corticospinal connections.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (LE2744/10‐1)
This publication has 47 references indexed in Scilit:
- The contribution of transcranial magnetic stimulation in the functional evaluation of microcircuits in human motor cortexFrontiers in Neural Circuits, 2013
- Diversity of layer 5 projection neurons in the mouse motor cortexFrontiers in Cellular Neuroscience, 2013
- Presenting data: can you follow a recipe?The Journal of Physiology, 2011
- Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical AreasPLoS Biology, 2011
- Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and researchClinical Neurophysiology, 2009
- Trial-to-Trial Variability of Single Cells in Motor Cortices Is Dynamically Modified during Visuomotor AdaptationJournal of Neuroscience, 2009
- Do Corticomotoneuronal Cells Predict Target Muscle EMG Activity?Journal of Neurophysiology, 2008
- Top-down laminar organization of the excitatory network in motor cortexNature Neuroscience, 2008
- Rapid Changes in Throughput from Single Motor Cortex Neurons to Muscle ActivityScience, 2007
- Motor Learning with Unstable Neural RepresentationsNeuron, 2007