Uncovering the Secrets of Prostate Cancer’s Radiotherapy Resistance: Advances in Mechanism Research
Open Access
- 3 June 2023
- journal article
- review article
- Published by MDPI AG in Biomedicines
- Vol. 11 (6), 1628
- https://doi.org/10.3390/biomedicines11061628
Abstract
Prostate cancer (PCa) is a critical global public health issue with its incidence on the rise. Radiation therapy holds a primary role in PCa treatment; however, radiation resistance has become increasingly challenging as we uncover more about PCa’s pathogenesis. Our review aims to investigate the multifaceted mechanisms underlying radiation therapy resistance in PCa. Specifically, we will examine how various factors, such as cell cycle regulation, DNA damage repair, hypoxic conditions, oxidative stress, testosterone levels, epithelial–mesenchymal transition, and tumor stem cells, contribute to radiation therapy resistance. By exploring these mechanisms, we hope to offer new insights and directions towards overcoming the challenges of radiation therapy resistance in PCa. This can also provide a theoretical basis for the clinical application of novel ultra-high-dose-rate (FLASH) radiotherapy in the era of PCa.Keywords
Funding Information
- National Natural Science Foundation of China (82271771)
- Natural Science Foundation of Beijing Municipality (7182164)
- Peking University Health Science Center Youth Cultivation Foundation (BMU2021PYB026)
- Peking University First Hospital Seed Foundation (2021SF05, 2021SF17)
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