A new index for assessing cerebral ventricular volume in idiopathic normal-pressure hydrocephalus: a comparison with Evans' index
- 1 June 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neuroradiology
- Vol. 62 (6), 661-667
- https://doi.org/10.1007/s00234-020-02361-8
Abstract
Purpose To recommend a new simple and explicit index termed the anteroposterior diameter of the lateral ventricle index (ALVI) for assessing brain ventricular size in neuroimaging and to compare Evans index (EI) between idiopathic normal pressure hydrocephalus (iNPH) patients and age-matched healthy elderly subjects. Methods Retrospective measurements of ventricular volume (VV), relative VV (RVV), the EI, and the ALVI were taken from thin-section CT scans for 23 pre-shunt-insertion iNPH patients and 62 age-matched healthy elderly volunteers. The area under the receiver operating characteristic (ROC) curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated to assess the effectiveness of ALVI scores for predicting VV. Results The correlations between VV or RVV and ALVI scores (VV, r = 0.957; RVV, r = 0.983) were significantly stronger than the corresponding correlations with EI scores (VV, r = 0.843; RVV, r = 0.840). The AUC for ALVI scores was significantly greater than the AUC for EI scores. Furthermore, with the inclusion of the ALVI, the NRI value was 0.14 and the IDI value was 0.14; these improvements were also statistically significant. Conclusion The ALVI is a more accurate and more explicitly defined marker of VV than the EI and assesses ventricular enlargement effectively. We suggest that ventricular enlargement of the healthy elderly be defined by ALVI > 0.50.Funding Information
- the Project of Shenzhen International Cooperation Foundation (GJHZ20180926165402083)
This publication has 18 references indexed in Scilit:
- Use of the proGAV Shunt Valve in Normal-Pressure HydrocephalusOperative Neurosurgery, 2011
- Evans' Index Revisited: The Need for an Alternative in Normal Pressure HydrocephalusNeurosurgery, 2011
- Brain Ventricular Size in Healthy Elderly: Comparison Between Evans Index and Volume MeasurementNeurosurgery, 2010
- Ventricular dilation: Association with gait and cognitionAnnals of Neurology, 2009
- Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative databaseBrain, 2008
- Comments on ‘Integrated discrimination and net reclassification improvements—Practical advice’Statistics in Medicine, 2007
- Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyondStatistics in Medicine, 2007
- Sexual dimorphism of the developing human brainProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1997
- Visual rating of magnetic resonance images of human cerebrospinal fluid spaces and white brain matter: Relation to sex and age in healthy volunteersMagnetic Resonance Imaging, 1992
- AN ENCEPHALOGRAPHIC RATIO FOR ESTIMATING THE SIZE OF THE CEREBRAL VENTRICLESAmerican Journal of Diseases of Children, 1942