Emerging SARS-CoV-2 variants of concern and potential intervention approaches
Open Access
- 12 July 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Critical Care
- Vol. 25 (1), 1-8
- https://doi.org/10.1186/s13054-021-03662-x
Abstract
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.Keywords
Funding Information
- Canadian Institutes of Health Research (OV3-170344, SBC-171482)
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