Concentrations of fatty acids among macrosomic neonates delivered by healthy women and women with type 1 diabetes mellitus
- 4 April 2020
- journal article
- research article
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 149 (3), 309-317
- https://doi.org/10.1002/ijgo.13151
Abstract
Objective To evaluate the concentration and profile of fatty acids (FAs) among macrosomic neonates delivered by healthy pregnant women and pregnant women with type 1 diabetes mellitus (T1DM). Methods A prospective study of women who delivered macrosomic neonates at a University Hospital Center, Zagreb, Croatia, 2016–2018. Maternal, umbilical vein, and arterial blood samples were collected immediately on delivery. After lipid extraction, total FAs in maternal, umbilical vein, and arterial serum samples were assessed by gas chromatography. Data were compared between women with T1DM and healthy control women. Results In total, 50 women were enrolled: 22 with T1DM and 28 control women. Neonates in the T1DM group had a higher ponderal index as compared with the control group (P=0.006). Umbilical vein insulin, insulin resistance, and leptin concentration were higher in the T1DM group than in the control group (all PP=0.004, PP=0.015, and P=0.014, respectively). Conclusion Macrosomic neonates delivered by women with T1DM had a higher Ponderal index, and higher concentrations of insulin, leptin, and FAs in the umbilical vein and artery as compared with control group newborns.Keywords
Funding Information
- Ministry of Science, Education and Technology of the Republic of Croatia
This publication has 19 references indexed in Scilit:
- Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant womenThe Journal of Maternal-Fetal & Neonatal Medicine, 2013
- International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in PregnancyDiabetes Care, 2010
- Obstetric and Perinatal Outcomes in Type 1 Diabetic PregnanciesDiabetes Care, 2009
- Increased neonatal fat mass, not lean body mass, is associated with maternal obesityAmerican Journal of Obstetrics and Gynecology, 2006
- Metabolic Changes in Diabetic PregnancyPublished by S. Karger AG ,2005
- Normal and Abnormal Fetal GrowthPublished by S. Karger AG ,2005
- Report of the Expert Committee on the Diagnosis and Classification of Diabetes MellitusDiabetes Care, 1997
- Factors affecting fetal growth and body compositionAmerican Journal of Obstetrics and Gynecology, 1995
- FETAL GROWTH CONTROL: THE ROLE OF INSULIN AND RELATED PEPTIDESClinical Endocrinology, 1984
- ESSENTIAL FATTY ACIDS AND FETAL BRAIN GROWTHThe Lancet, 1976