Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1
- 2 December 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 86 (1), 475-483
- https://doi.org/10.1021/acs.joc.0c02214
Abstract
Chaetolactam A (1), an unprecedented azaphilone derivative bearing a unique 9-oxa-7-azabicyclo[4.2.1]octan-8-onering system, together with two new compounds, 11-epi-chaetomugilide B (2) and chaetomugilide D (3) was isolated from an endophytic fungus, Chaetomium sp. g1. Notably, extensive NMR data analyses, NMR calculations with DP4 and DP4+ analyses, ECD calculations, and the RDC method were employed to establish the structure of 1. Furthermore, 2 exhibited potent apoptosis induction activity by mediating caspase-3 activation and PARP degradation at 3 μM in HL-60.Keywords
Funding Information
- National Natural Science Foundation of China (81874298, 81903520)
- Chinese Academy of Sciences
- Yunnan Science Fund for Distinguished Young Scholars (2019FJ002)
- Second Tibetan Plateau Scientific Expedition and Research (2019QZKK0502)
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