Prospective Longitudinal Serosurvey of Healthcare Workers in the First Wave of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic in a Quaternary Care Hospital in Munich, Germany
Open Access
- 3 January 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 73 (9), e3055-e3065
- https://doi.org/10.1093/cid/ciaa1935
Abstract
High infection rates among health care personnel in an uncontained pandemic can paralyze health systems due to staff shortages. Risk constellations and rates of seroconversion for health care workers during the first wave of the SARS-CoV-2 pandemic are still largely unclear. Health care personnel (n=300) on different organizational units in the LMU Munich University Hospital were included and followed in this prospective longitudinal study in the period of March 24 until July 7, 2020. Participants were monitored in intervals of two to six weeks using different antibody assays for serological testing and questionnaires to evaluate risk contacts. In a subgroup of infected participants, we obtained nasopharyngeal swabs to perform whole genome sequencing for outbreak characterization. Health care workers involved in patient care on dedicated COVID-19 wards or on regular non-COVID-19 wards showed a higher rate of SARS-CoV-2 seroconversion compared to staff in the emergency department and non-frontline personnel. The landscape of risk contacts in these units was dynamic, with a decrease of unprotected risk contacts in the emergency department and an increase on non-COVID-19 wards. Both, the intensity and number of risk contacts, were associated with higher rates of seroconversion. On regular wards, staff infections tended to occur in clusters, while infections on COVID-19 wards were less frequent and apparently independent of each other. The risk of SARS-CoV-2 infection for front-line health care workers was increased during the first pandemic wave in Southern Germany. Stringent measures for infection control are essential to protect all patient-facing staff during the ongoing pandemic.Funding Information
- NaFoUniMedCovid19 (01KX2021)
This publication has 22 references indexed in Scilit:
- Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since ExposureAnnals of Internal Medicine, 2020
- Nosocomial Transmission of Coronavirus Disease 2019: A Retrospective Study of 66 Hospital-acquired Cases in a London Teaching HospitalClinical Infectious Diseases, 2020
- Prevalence of Coronavirus Disease 2019 Infection and Outcomes Among Symptomatic Healthcare Workers in Seattle, WashingtonClinical Infectious Diseases, 2020
- The impending storm: COVID-19, pandemics and our overwhelmed emergency departmentsThe American Journal of Emergency Medicine, 2020
- SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patientsJournal of Clinical Virology, 2020
- Viral dynamics in asymptomatic patients with COVID-19International Journal of Infectious Diseases, 2020
- Temporal dynamics in viral shedding and transmissibility of COVID-19Nature Medicine, 2020
- COVID-19 and Italy: what next?The Lancet, 2020
- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, ChinaJAMA, 2020
- Protecting health-care workers from subclinical coronavirus infectionThe Lancet Respiratory Medicine, 2020