The mcr-9 Gene of Salmonella and Escherichia coli Is Not Associated with Colistin Resistance in the United States
- 22 July 2020
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 64 (8)
- https://doi.org/10.1128/aac.00573-20
Abstract
Reports of transmissible colistin resistance show the importance of comprehensive colistin resistance surveillance. Recently, a new allele of the mobile colistin resistance (mcr) gene family designated mcr-9 was reported, which shows variation in genetic context and colistin susceptibility. We tested over one hundred Salmonella enterica and Escherichia coli with mcr-9 from the National Antimicrobial Resistance Monitoring System (NARMS) in the United States for their susceptibility to colistin and found that every isolate was susceptible with an MIC of ≤ 1 μg/mL. Long-read sequencing of twelve isolates revealed mcr-9 on IncHI plasmids that were either independent or integrated into the chromosome. Overall, these results demonstrate that caution is necessary when determining the clinical relevance of new resistance genes.Keywords
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