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Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership

Sabnam Parbin, Subha Damodharan,
Published: 28 May 2021
 in Yeast
Yeast ; doi:10.1002/yea.3653

Abstract: Posttranslational modifications play a crucial role in regulating gene expression. Among these modifications, arginine methylation has recently attracted tremendous attention due to its role in multiple cellular functions. This review discusses the recent advances that have established arginine methylation as a major player in determining cytoplasmic messenger RNA (mRNA) fate. We specifically focus on research that implicates arginine methylation in regulating mRNA translation, decay, and RNA granule dynamics. Based on this research, we highlight a few emerging future avenues that will lead to exciting discoveries in this field.
Keywords: arginine methylation / cytoplasmic mRNA fate / methyltransferases / mRNA decay / RGG-motif proteins / translation

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