Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing
Open Access
- 10 February 2021
- Vol. 26 (4), 929
- https://doi.org/10.3390/molecules26040929
Abstract
Copper-doped zinc oxide nanoparticles (NPs) CuxZn1−xO (x = 0, 0.01, 0.02, 0.03, and 0.04) were synthesized via a sol-gel process and used as an active electrode material to fabricate a non-enzymatic electrochemical sensor for the detection of glucose. Their structure, composition, and chemical properties were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) and Raman spectroscopies, and zeta potential measurements. The electrochemical characterization of the sensors was studied using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Cu doping was shown to improve the electrocatalytic activity for the oxidation of glucose, which resulted from the accelerated electron transfer and greatly improved electrochemical conductivity. The experimental conditions for the detection of glucose were optimized: a linear dependence between the glucose concentration and current intensity was established in the range from 1 nM to 100 μM with a limit of detection of 0.7 nM. The proposed sensor exhibited high selectivity for glucose in the presence of various interfering species. The developed sensor was also successfully tested for the detection of glucose in human serum samples.Keywords
Funding Information
- European Union (PO FEDER-FSE Bourgogne 2014/2020 programs)
- EIPHI Graduate School (ANR-17-EURE-0002)
This publication has 83 references indexed in Scilit:
- Methods for the determination of limit of detection and limit of quantitation of the analytical methodsChronicles of Young Scientists, 2011
- Multidepth screening of living cells using optical waveguidesBiosensors and Bioelectronics, 2008
- Far-Infrared Absorption by Acoustic Phonons in Titanium Dioxide NanopowdersJournal of Nanoelectronics and Optoelectronics, 2006
- Electrochemical non-enzymatic glucose sensorsAnalytica Chimica Acta, 2006
- A study of magnetic and optical properties of Cu‐doped ZnOPhysica Status Solidi (b), 2004
- Particle Size Dependency of Ternary Diagrams at the Nanometer Scale: Evidence of TiO2 Clusters in Fe-Based SpinelsThe Journal of Physical Chemistry B, 2003
- Ab initioHartree-Fock investigation of the structural, electronic, and magnetic properties ofPhysical Review B, 1999
- Structural characterization of hot wall deposited cadmium selenide thin filmsSemiconductor Science and Technology, 1998
- Separation of particle size and lattice strain in integral breadth measurementsActa Crystallographica, 1966
- Electronegativity values from thermochemical dataJournal of Inorganic and Nuclear Chemistry, 1961