Regulatory T cells isolated from endometriotic peritoneal fluid express a different number of Toll-like receptors
Open Access
- 1 January 2020
- journal article
- research article
- Published by Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein in Einstein (São Paulo)
- Vol. 18, eAO5294
- https://doi.org/10.31744/einstein_journal/2020AO5294
Abstract
Objective: To analyze and compare the expression of Toll-like receptors by regulatory T cells present in the peritoneal fluid of patients with and without endometriosis. Methods: Regulatory T cells were isolated from peritoneal fluid of women with and without endometriosis, collected during surgery, and mRNA was extracted for analysis of Toll-like receptors expression by reverse-transcriptase polymerase chain reaction. Results: Patients with endometriosis presented regulatory T cells expressing a larger number and variety of Toll-like receptors when compared to regulatory T cells from patients in the Control Group. Toll-like receptor-1 and Toll-like receptor-2 in regulatory T cells were expressed in both groups. All other expressed Toll-like receptors types were only found in regulatory T cells from the Endometriosis Group. Conclusion: Patients with endometriosis had peritoneal regulatory T cells expressing various Toll-like receptors types.This publication has 25 references indexed in Scilit:
- Endometriosis: A Disease That Remains EnigmaticISRN Obstetrics and Gynecology, 2013
- The adjuvant effect of TLR agonists on CD4+ effector T cells is under the indirect control of regulatory T cellsEuropean Journal of Immunology, 2011
- Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosisFertility and Sterility, 2010
- Toll‐like receptor signalling on Tregs: to suppress or not to suppress?Immunology, 2008
- Regulatory T Cells and Immune ToleranceCell, 2008
- Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cellsImmunology, 2007
- CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cellsImmunology Letters, 2007
- Toll-Like Receptor 8-Mediated Reversal of CD4 + Regulatory T Cell FunctionScience, 2005
- Toll-like receptors as an escape mechanism from the host defenseTrends in Microbiology, 2004
- Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by LipopolysaccharideThe Journal of Experimental Medicine, 2003