Diagnosis of Early Mycosis Fungoides
Open Access
- 19 September 2021
- journal article
- review article
- Published by MDPI AG in Diagnostics
- Vol. 11 (9), 1721
- https://doi.org/10.3390/diagnostics11091721
Abstract
Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphomas, generally has a favorable clinical course. Early MF typically presents erythematous patches and/or plaques and lasts for many years without affecting the life expectancy. Only limited cases progress to develop skin tumors, with subsequent lymph nodes and rarely visceral organ involvement. One of the clinical problems in early MF is the difficulty in differentiating the disease from benign inflammatory disorders (BIDs), such as atopic dermatitis, chronic eczema, and psoriasis. In some MF cases, clinical and pathological findings are similar to those of BIDs. However, the accurate diagnosis of early MF is quite important, as inappropriate treatment including immunosuppressants can cause unfavorable or even fatal outcomes. This article focuses on general methods and novel tools for diagnosis of early MF.Funding Information
- Ministry of Education, Culture, Sports, Science and Technology (20K08683)
This publication has 58 references indexed in Scilit:
- Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)Blood, 2011
- Defining early mycosis fungoidesJournal of the American Academy of Dermatology, 2005
- WHO-EORTC classification for cutaneous lymphomasBlood, 2005
- The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitmentNature, 2005
- Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemiaBlood, 2004
- Low CD7 Expression in Benign and Malignant Cutaneous Lymphocytic InfiltratesThe American Journal of Dermatopathology, 2002
- Analysis of Clonality in Cutaneous T Cell Lymphoma and Associated DiseasesAnnals of the New York Academy of Sciences, 2001
- Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of Southern blot analysis with polymerase chain reaction amplification of the T-cell receptor-γ geneBritish Journal of Dermatology, 1997
- Clonotypic Analysis of T Cells Infiltrating the Skin of Patients with Atopic Dermatitis: Evidence for Antigen-Driven Accumulation of T CellsHuman Immunology, 1996
- Leu-8/CD7 antigen expression by CD3+ T cells: Comparative analysis of skin and blood in mycosis fungoides/Sézary syndrome relative to normal blood valuesJournal of the American Academy of Dermatology, 1990