Information Integration and Mesoscopic Cortical Connectivity during Propofol Anesthesia
- 1 March 2020
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 132 (3), 504-524
- https://doi.org/10.1097/aln.0000000000003015
Abstract
Coupling of neuronal oscillations between brain regions is correlated with higher level brain activity Permutation cross mutual information can be used to evaluate information integration in the electroencephalogram during anesthesia. Using electrocorticography in subjects anesthetized with propofol, the genuine permutation cross mutual information demonstrated that, with loss of consciousness, there was a loss of efficient global information transmission and increased local functional segregation in the cortical network The neurophysiologic mechanisms of propofol-induced loss of consciousness have been studied in detail at the macro (scalp electroencephalogram) and micro (spiking or local field potential) scales. However, the changes in information integration and cortical connectivity during propofol anesthesia at the mesoscopic level (the cortical scale) are less clear. The authors analyzed electrocorticogram data recorded from surgical patients during propofol-induced unconsciousness (n = 9). A new information measure, genuine permutation cross mutual information, was used to analyze how electrocorticogram cross-electrode coupling changed with electrode-distances in different brain areas (within the frontal, parietal, and temporal regions, as well as between the temporal and parietal regions). The changes in cortical networks during anesthesia—at nodal and global levels—were investigated using clustering coefficient, path length, and nodal efficiency measures. In all cortical regions, and in both wakeful and unconscious states (early and late), the genuine permutation cross mutual information and the percentage of genuine connections decreased with increasing distance, especially up to about 3 cm. The nodal cortical network metrics (the nodal clustering coefficients and nodal efficiency) decreased from wakefulness to unconscious state in the cortical regions we analyzed. In contrast, the global cortical network metrics slightly increased in the early unconscious state (the time span from loss of consciousness to 200 s after loss of consciousness), as compared with wakefulness (normalized average clustering coefficient: 1.05 ± 0.01 vs. 1.06 ± 0.03, P = 0.037; normalized average path length: 1.02 ± 0.01 vs. 1.04 ± 0.01, P = 0.021). The genuine permutation cross mutual information reflected propofol-induced coupling changes measured at a cortical scale. Loss of consciousness was associated with a redistribution of the pattern of information integration; losing efficient global information transmission capacity but increasing local functional segregation in the cortical network.This publication has 58 references indexed in Scilit:
- Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousnessProceedings of the National Academy of Sciences of the United States of America, 2012
- Intrinsic Organization of the Anesthetized BrainJournal of Neuroscience, 2012
- Dissociable Network Properties of Anesthetic State TransitionsAnesthesiology, 2011
- Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesiaProceedings of the National Academy of Sciences of the United States of America, 2010
- Complex network measures of brain connectivity: Uses and interpretationsNeuroImage, 2010
- Estimating coupling direction between neuronal populations with permutation conditional mutual informationNeuroImage, 2010
- Multiscale permutation entropy analysis of EEG recordings during sevoflurane anesthesiaJournal of Neural Engineering, 2010
- Direct brain recordings fuel advances in cognitive electrophysiologyTrends in Cognitive Sciences, 2010
- Utility of Independent Component Analysis for Interpretation of Intracranial EEGFrontiers in Human Neuroscience, 2010
- The Effect of Sevoflurane and Isoflurane Anesthesia on Interictal Spike Activity Among Patients with Refractory EpilepsyAnesthesia & Analgesia, 1999