Evolving challenges to model human diseases for translational research
- 1 May 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 380 (2), 305-311
- https://doi.org/10.1007/s00441-019-03134-3
Abstract
Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.This publication has 45 references indexed in Scilit:
- Extrapolating from Animals to HumansScience Translational Medicine, 2012
- The Value of Unusual Animal Models for Alcohol ResearchAlcohol: Clinical and Experimental Research, 2011
- Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal ResearchPLoS Biology, 2010
- Why animal studies are often poor predictors of human reactions to exposureJournal of the Royal Society of Medicine, 2009
- Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn PigsScience, 2008
- The porcine lung as a potential model for cystic fibrosisAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2008
- The mouse ascending: perspectives for human-disease modelsNature, 2007
- Translating animal research into clinical benefitBMJ, 2007
- Comparison of treatment effects between animal experiments and clinical trials: systematic reviewBMJ, 2006
- Where is the evidence that animal research benefits humans?BMJ, 2004